Adipose Tissue Dysfunction and Alcoholic Liver Disease
نویسندگان
چکیده
منابع مشابه
Adipose Tissue Dysfunction and Alcoholic Liver Disease
Although much progress has been made over last three decades of research on the mechanisms underlying alcoholic liver disease (ALD), it remains an important health problem in the United States. ALD ranks among the major causes of morbidity and mortality in the world, and affects millions of patients worldwide each year [1]. The disease process is characterized by early steatosis, steatohepatiti...
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Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Its pathogenesis is complex and not yet fully understood. Over the years many studies have proposed various pathophysiological hypotheses, among which the currently most widely accepted is the "multiple parallel hits" theory. According to this model, lipid accumulation in the hepatocytes and insulin re...
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BACKGROUND Fatty liver is a major cause of obesity-related morbidity and mortality. The aim of this study was to identify early metabolic alterations associated with liver fat accumulation in 50- to 55-year-old men (n = 49) and women (n = 52) with and without NAFLD. METHODS Hepatic fat content was measured using proton magnetic resonance spectroscopy (1H MRS). Serum samples were analyzed usin...
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Background and Aim: A great interest for determining the particular mechanisms underlying lipogenesis and adipogenesis has been raised among researchers in order to fight obesity. We aimed to investigate the gene expression of FAS and its role in regulation of lipogenesis and adipogenesis in visceral adipose tissues from obese and normal-weight subjects. materials and Methods: A total of.parti...
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BACKGROUND AND AIMS Alström syndrome (AS) is a recessive monogenic syndrome characterized by obesity, extreme insulin resistance and multi-organ fibrosis. Despite phenotypically being high risk of non-alcoholic fatty liver disease (NAFLD), there is a lack of data on the extent of fibrosis in the liver and its close links to adipose in patients with AS. Our aim was to characterize the hepatic an...
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ژورنال
عنوان ژورنال: Journal of Liver Research, Disorders & Therapy
سال: 2015
ISSN: 2471-1381
DOI: 10.15406/jlrdt.2015.01.00001